Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy

Inclusion criteria

• Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS), Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission at the time of enrollment
• Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI) and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative allogeneic HSCT
• Between 18 and 70 years of age.
• Are English speaking.
• Have capacity to give consent.

Healthy Control Inclusion Criteria:

• Have no diagnosis of cancer except basal cell carcinoma
• Between 18 and 70 years of age.
• Are English speaking.
• Have capacity to give consent

Exclusion criteria

• Patients with signs and/or symptoms of central nervous system disease as determined by their physician or by a brain MRI, either at the time of enrollment or during the study period.
• With disease progression at the time of enrollment or during the study period
• With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
• With a history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness
• With standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

• Exposure to chemotherapy or radiation therapy for any medical condition
• With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
• With a history of neurological disorders, neurodegenerative disease, or traumatic brain injury with loss of consciousness
• With standard contraindications to MRI examinations