IRCCS Policlinico San Donato
San Donato Milanese, MI, 20097, Italy
Location status: Recruiting
Location contact
Alessandra Sala, MD
CONTACT
Alessandra Sala, MD
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07453251
The aim of the study is to analyse the resected portion of aneurysmatic ascending aorta in order to assess its strength to rupture, standardise the various measurements performed within the lab and try to correlate these qualitative results with quantitative results (regarding aortic diameter, valve morphology and aortic wall thickness).
Interested in participating?
Request Info18 year and older
All sexes
Observational
San Donato Milanese, MI, 20097, Italy
Location status: Recruiting
Alessandra Sala, MD
CONTACT
Alessandra Sala, MD
PRINCIPAL_INVESTIGATOR
The aortic wall is subjected to mechanical stresses in radial, circumferential, and longitudinal directions. The amount of these shear stresses varies with the distribution of velocity across the vessel lumen and with local vessel geometry.
Diseases affecting the thoracic aorta can be categorized into acute and chronic. Chronic aortic pathologies are chronic aortic dissections and aortic aneurysms.
Today, there are computational tools available to permit the calculation of stresses of the aortic wall.
For the above-mentioned reasons, this study becomes of extreme interest as it may be capable of further assessing the mechanical properties of the dilated aortic tissue, its' strength to rupture and stiffness, in order to provide an overview of the fragility of ascending aortic aneurysms. This parameter, associated to the diameter of the pathological aorta, may provide an additional tool regarding the clinical history of patients and insight concerning surgical indication.
Matter of factly, knowing the risk of rupture based on diameter may have strong implications on the preoperative evaluation of patients and the decision-making process.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: During laboratory testing
Define the strength to rupture of the removed aortic segments and its relation with the circumferential and longitudinal direction along the aortic axis.
Time frame: From surgery to laboratory testing
Evaluate multiple characteristics of the surgically excised pathologically enlarged aortic segments: shape alteration, tensile strength, elasticity capacity.
Time frame: During laboratory testing
Assess from a methodological point of view the various aspects and results of the different test and identify the ideal testing method (uniaxial vs biaxial)
IRCCS Policlinico S. Donato
Other
Strength Tracking From Wall Tichness Over Aortic Biomechanics
Acronym: STORM
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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