Skip to main content
OpenTrials
Recruiting

NCT Number: NCT05426408

Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Myocardial Infarction with Nonobstructive Coronary Arteries Cardiovascular Diseases Heart Diseases Infarction Ischemia MINOCA Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

35 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
  • age 35-80 years
  • reading and writing proficiency in Swedish

Exclusion criteria

  • Claustrofobia
  • Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
  • Asthma or severe chronic obstructive lung disease
  • eGFR < 30 ml/min
  • spontaneous coronary artery dissection
  • acute pulmonary embolism
  • acute myocardial infarction type 2
  • cardiomyopathy other than takotsubo syndrome
  • a previous myocardial infarction due to CAD

Treatment and study plan

Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

Diagnostic Test

Myocardial perfusion mapping will be investigated after administration of adenosine

Primary outcomes

  1. Diagnostic yield

    Time frame: Through investigation completion, usually 2 hours

    To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis

Secondary outcomes

  1. Prevalence of CMD in MINOCA

    Time frame: Through investigation completion, usually 2 hours

    To determine the proportion of patients with the working diagnosis of MINOCA who have CMD.

  2. Prevalence of CMD in different final MINOCA diagnoses

    Time frame: Through investigation completion, usually 2 hours

    To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group

  3. Angina pectoris

    Time frame: 3 Months

    To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD

Study contacts

Contact information is provided by the study sponsor or research team.

Peder Sörensson, MD

CONTACT

[email protected]

+46812370000

Per Tornvall, MD

CONTACT

[email protected]

+468616100

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Region Stockholm

Registry information

Official study title

Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries

Acronym: SMINC-3

Important dates

Study start
2022
Primary completion
2025
Study completion
2026
First posted
Jun 22, 2022
Registry last updated
Mar 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.