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Completed

NCT Number: NCT00619086

Steroid Before Thyroidectomy

We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

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Key information

Conditions

Thyroid Surgery for Benign Disease Nausea Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of visceral- and transplant surgery

Bern, 3010, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing thyroid surgery for benign disease

Exclusion criteria

  • Depression
  • Chronic pain disorder
  • Insulin dependent diabetes mellitus
  • History of PONV
  • Pregnancy
  • Age < 18 years
  • Received antiemetic therapy within 48 hours

Treatment and study plan

Dexamethason Helvepharm ®

Drug

8 mg Dexamethason i.v. 45 minutes prior to surgery

Placebo

Drug

100 ml sodium chloride i.v. 45 minutes prior to surgery

Primary outcomes

  1. Nausea

    Time frame: 0-72 hours postoperative

Secondary outcomes

  1. Pain, vocal function

    Time frame: 0-72 hours postoperative

Sponsors and collaborators

Lead sponsor

University of Bern

Other

Registry information

Official study title

Does a Single Dose of Steroid Before Thyroidectomy Improve Postoperative Nausea, Pain and Vocal Function?

Important dates

Study start
2005
Study completion
2007
First posted
Feb 20, 2008
Registry last updated
Jun 9, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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