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NCT Number: NCT07601633

Split-Belt Gait Retraining in Subacute Stroke

Stroke is a leading cause of long-term disability in adults. Although many individuals regain independent walking ability following stroke, nearly 50% experience persistent gait impairments characterized by asymmetrical walking patterns, slower walking speed, impaired balance, and increased fall risk. These persistent mobility limitations highlight the continued need for innovative rehabilitation strategies that improve gait function during stroke recovery. Split-belt treadmill walking (SBTW), in which each leg walks at a different belt speed, has demonstrated potential to improve step length symmetry in individuals with chronic stroke. However, the effects of SBTW during the subacute stage of stroke recovery, within the first 9 months post-stroke when neuroplasticity may be heightened, remain largely unknown. In addition, previous SBTW studies have not integrated active physiotherapist-led gait retraining into the intervention, despite physiotherapist-led gait rehabilitation representing standard clinical care following stroke. The purpose of this randomized controlled trial is to compare physiotherapist-led gait retraining using a traditional treadmill training protocol to physiotherapist-led gait retraining integrated with a split-belt treadmill training protocol during the first 9 months post-stroke. The study aims to examine the effectiveness of the use of split-belt treadmill training to augment physiotherapist-led gait retraining to improve between-leg gait symmetry and overground walking speed.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

GF Strong Rehabilitation Centre

Vancouver, British Columbia, V5Z 2G9, Canada

Location contact

Beier Lin

CONTACT

[email protected]

2508997489

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • unilateral stroke resulting in hemiparesis
  • less than 9 months post-stroke
  • ability to walk ten metres with or without walking aids
  • ability to stand without support for five minutes
  • English speaking

Exclusion criteria

  • medically unfit to participate e.g. cardiac or respiratory disease limiting ability to perform walking tasks
  • neuromuscular impairment, other than stroke, limiting mobility, e.g. ankle sprain, joint disease such as severe arthritis
  • cognitive/communication impairment impacting ability to follow instructions
  • diagnosis of clinical depression or anxiety disorders requiring medication

Treatment and study plan

Split-belt walking training

Behavioral

Participants randomized to the split-belt training group will complete 12 sessions of split-belt treadmill walking training over 4 weeks, delivered 3 times per week. Training will be performed on an instrumented split-belt treadmill and will include split-belt and tied-belt walking conditions. A physiotherapist will provide gait retraining during each session.

Primary outcomes

  1. Step length symmetry

    Time frame: Baseline, immediately post-intervention, and at 1-month follow-up

  2. Self-selected gait speeds

    Time frame: Baseline, immediately post-intervention, and at 1-month follow-up

    Self-selected gait speeds at both comfortable and fast speed will be measured by overground 10 meter walk tests

Study contacts

Contact information is provided by the study sponsor or research team.

Beier Lin

CONTACT

[email protected]

Courtney Pollock, PT PhD

CONTACT

[email protected]

604-714-4117

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

Physiotherapist-Led Split-Belt Treadmill Gait Retraining for Individuals With Subacute Stroke: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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