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NCT Number: NCT04622501

Spinal Epidural Lipomatosis: a Case Report and Review of the Literature

Introduction Lumbar spinal epidural lipomatosis (SEL) is a rare condition defined by an excessive deposition of adipose tissue in the lumbar spinal canal. The objective of this case report is to document a clinical case of SEL presenting within a multidisciplinary spine clinic and to compare our clinical findings and management with the current literature.

Case presentation A 51-year-old female presented at a spine clinic with low back pain, bilateral leg pain and difficulty walking. MR imaging of the lumbar spine showed L4-L5 and L5-S1 degenerative disk disease with evidence of severe central canal stenosis due to extensive epidural lipomatosis. The patient was initially advised to lose weight, undergo a course of physiotherapy, and consult with the pain clinic. Because of lack of improvement, the patient was scheduled for L4-S1 posterior spinal decompression and L4-L5 posterior spinal instrumented fusion.

Discussion The discussion will include the diagnosis of SEL, imaging appearance, its risk factors, etiology and management.

Conclusion This case report describes a case of lumbar spinal stenosis due to SEL with neurological symptoms. Some risk factors have also been identified in the literature. MRI is considered as the reference standard for its diagnosis. The therapeutic approach of patients with SEL is not standardized. Thus, reporting and investigating the diagnostic process and treatment of this patient will positively contribute to better management for other future patients.

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Key information

Conditions

Spinal Stenosis Bone Diseases Musculoskeletal Diseases Spinal Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CMCC

Toronto, Ontario, M4T1E5, Canada

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults patient with a clinical diagnosis of Spinal Epidural Lipomatosis (MRI and clinical diagnosis)

Exclusion criteria

  • Absence of clinical diagnosis of Spinal Epidural Lipomatosis

Treatment and study plan

posterior spinal decompression and posterior spinal instrumented fusion

Procedure

posterior spinal decompression and posterior spinal instrumented fusion performed on a patient with Spinal Epidural Lipomatosis

Primary outcomes

  1. Low back pain

    Time frame: 3 months before surgery

    Visual Pain Scale (0-10)

  2. Low back pain

    Time frame: 6 weeks after surgery

    Visual Pain Scale (0-10)

  3. Distance Walking

    Time frame: 3 months before surgery

    Distance walking (meter)

  4. Distance Walking

    Time frame: 6 weeks after surgery

    Distance walking (meter)

  5. Low back pain

    Time frame: 3 months after surgery

    Visual Pain Scale (0-10)

  6. Low back pain

    Time frame: 1 year after surgery

    Visual Pain Scale (0-10)

  7. Distance walking

    Time frame: 3 months after surgery

    Distance walking (meter)

  8. Distance walking

    Time frame: 1 year after surgery

    Distance walking (meter)

Sponsors and collaborators

Lead sponsor

Canadian Memorial Chiropractic College

Other

Registry information

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Nov 10, 2020
Registry last updated
Nov 12, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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