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NCT Number: NCT07608289

Socket Preservation Using Autogenous Dentin

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.

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Key information

Conditions

Tooth Extraction Site Healing

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Ostrava

Ostrava, 70852, Czechia

Location status: Recruiting

Location contact

Martin Starosta, Assoc. Prof. MUDr., Ph.D.

CONTACT

[email protected]

Petr Jalůvka, MDDr.

PRINCIPAL_INVESTIGATOR

About this study

The study evaluates four different approaches to alveolar ridge preservation after tooth extraction. Eligible patients aged 18-70 years will undergo minimally traumatic extraction. Four treatment modalities will be compared: 1) Spontaneous healing secured with a stitch (control group), 2) Application of collagen sponge (Parasorb Cone, Resorba, Germany) secured with a stitch, 3) Application of a tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic) covered with a collagen sponge (Parasorb Cone) and secured with a stitch. 4) Application of autogenous dentin, covered with a collagen sponge (Parasorb Cone) and secured with a stitch. Alveolar ridge dimensions will be measured on CBCT before extraction and again after six months. Primary outcomes include the absolute and relative change in ridge width and height at 1 mm, 3 mm, and 5 mm below the highest point of the alveolar bone as per Del Canto-Díaz, 2019. Patient factors (periodontal biotype, soft tissue phenotype, and vestibular thickness of the alveolar bone) will be recorded to allow subgroup analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-70 years
  • no active periodontitis
  • signed informed consent with participation in the study
  • need for extraction of teeth other than third molars
  • patients requesting only standard/reimbursed care

Exclusion criteria

  • drug or alcohol abuse
  • ongoing chemotherapy
  • ongoing radiotherapy
  • pregnancy
  • ongoing treatment of osteoporosis or other biological treatment with MRONJ risk
  • low compliance
  • patients asking for premium care

Treatment and study plan

Tooth extraction left to heal spontaneously

Procedure

Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material.

Tooth extraction plus collagen sponge

Procedure

Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.

Tooth extraction plus tricalcium phosphate

Procedure

Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Tooth extraction plus autogenous dentin

Procedure

Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Primary outcomes

  1. Alveolar bone width

    Time frame: 6 months

    Absolute and relative change in the alveolar bone width at 1 mm, 3 mm, and 5 mm below the alveolar crest measured from CBCT imagery.

Study contacts

Contact information is provided by the study sponsor or research team.

Petr Jalůvka, MDDr.

CONTACT

[email protected]

+420 596 623 518

Sponsors and collaborators

Lead sponsor

University of Ostrava

Other

Collaborators

  • Private dental practice Jalůvka
  • University Hospital Ostrava

Registry information

Official study title

Socket Preservation After Tooth Extraction Using Autogenous Dentin in Comparison With Other Techniques

Acronym: SPAD

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
May 27, 2026
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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