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NCT Number: NCT06624982

Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Recruiting

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Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Marquette University School of Dentistry Graduate Periodontics Clinic

Milwaukee, Wisconsin, 53233, United States

Location status: Recruiting

Location contact

Arndt Guentsch, DMD, PhD, MHBA, MS

CONTACT

[email protected]

4142886089

Vrisiis Kofina, DDS, MS

CONTACT

[email protected]

4142886521

Vrisiis Kofina, DDS, MS

PRINCIPAL_INVESTIGATOR

About this study

The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (18-75 years)
  • Good general health (controlled conditions)
  • Controlled periodontal disease
  • Scheduled for single tooth extraction with bone graft placement and resorbable membrane
  • Tooth to be extracted must have adjacent teeth
  • Socket wall integrity

Exclusion criteria

  • Smoking
  • Pregnancy
  • Active periodontal disease
  • Systemic conditions that affect healing
  • Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.

Treatment and study plan

observational study

Other

Observational study; alveolar ridge preservation

Primary outcomes

  1. Buccolingual ridge width

    Time frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

    Buccolingual ridge width will be measured through a stent via ridge mapping calipers. The measurement locations will be at 1mm, 3mm and 5mm from the midbuccal crest. The same measurements will be recorded at all selected time points.

  2. Ridge height

    Time frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

    Ridge height will be measured through a stent via a periodontal probe as the distance between bone and predetermined landmarks on the stent. The measurement locations will be mesial buccal, midbuccal, distal buccal, mesial lingual, midlingual and distal lingual. The same measurements will be recorded at all selected time points.

Study contacts

Contact information is provided by the study sponsor or research team.

Samah Rady, DDS

CONTACT

[email protected]

9497962173

Vrisiis Kofina, DDS, MS

CONTACT

[email protected]

4142886521

Sponsors and collaborators

Lead sponsor

Marquette University

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Oct 3, 2024
Registry last updated
Nov 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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