Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study

In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH). Based on the Finnish social security number, these individuals will be linked to the the national registers of Statistics Finland and Finnish Social and Health Data Permit Authority Findata including incomes, sociodemographic factors, education, occupation, criminal records as well as to the national registers including the bought pharmaceuticals, comorbidities and causes of death. For each study case, 10 randomly selected control cases, matched with age, sex and geographical area, will be used.

The aim of the study is to examine:

* 1) The prevalence of criminal and other disruptive behaviour in groups of different neurodegenerative diseases prior to and after the diagnosis * 2) Changes in employment, residency,income, and marital status prior to and after the neurodegenerative disease diagnosis * 3) Hospital diagnoses and reimbursable drugs prior to and after the diagnosis * 4) Causes of death in patients with neurodegenerative disease to study excess mortality of the patients

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Neurodegenerative Diseases Alzheimer Disease Amyotrophic Lateral Sclerosis Arterial Occlusive Diseases Arteriosclerosis Autonomic Nervous System Diseases Basal Ganglia Diseases Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Chorea Cognition Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Corticobasal Degeneration Cranial Nerve Diseases Dementia Dementia, Vascular Dyskinesias Eye Diseases Frontotemporal Dementia Frontotemporal Lobar Degeneration Genetic Diseases, Inborn Heredodegenerative Disorders, Nervous System Huntington Disease Intracranial Arterial Diseases Intracranial Arteriosclerosis Leukoencephalopathies Lewy Body Disease Mental Disorders Metabolic Diseases Motor Neuron Disease Movement Disorders Multiple System Atrophy Nervous System Diseases Neurocognitive Disorders Neurologic Manifestations Neuromuscular Diseases Nutritional and Metabolic Diseases Ocular Motility Disorders Ophthalmoplegia Paralysis Parkinson Disease Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Primary Dysautonomias Progressive Supranuclear Palsy Proteostasis Deficiencies Signs and Symptoms Spinal Cord Diseases Supranuclear Palsy, Progressive Synucleinopathies TDP-43 Proteinopathies Tauopathies Vascular Dementia Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Kuopio University Hospital

Kuopio, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The diagnosis of neurodegenerative disease (ICD-10) in KUH or OUH between the years 2010-2021
Age, sex and residency matched controls (Every research patient has 10 controls matched by age, gender, and place of residency)

Exclusion criteria

Patients will be divided into different diagnostic groups based on the accepted diagnostic criteria in use. If some of the formed groups contain less than 5 subjects, the disease group in question is excluded from the analyses in order to ensure the privacy protection of the subjects

Treatment and study plan

Primary outcomes

Criminal behaviour: Type of offence, time of offence and other disruptive behaviour

Time frame: 1996-2020

Statistics Finland, Statistics on offences and coercive measures. Criminal behaviour is investigated utilising the reports of offences received by the police. The classification of offences is based on the three- or six-numbered offence classification by Statistics Finland, which enables the examination of different offences including e.g., violence, property, and traffic offences. The data extracted from the register include the type of the offence and time. Also, other disruptive behaviour based on the captures performed by the police (e.g., captures of intoxicated persons) is extracted.
Socio-demographic data

Time frame: 1987-2021

Employment, residency, Income, Marital status. Socio-demographic outcome data is extracted from Statistics Finland, FOLK Basic data module. Possible changes in employment and residency are examined, and mortality and emigration will be considered as censoring factors
Hospital diagnoses

Time frame: 1994-2021

Hospital diagnoses from the National Discharge Register. The National Discharge Register contains information of all hospitalizations after 1969, including ICD-8, ICD-9, and ICD-10 classifications to detect comorbidities of the patients. Two registers, "Terveydenhuollon hoitoilmoitusrekisteri (Hilmo)" and "Perusterveydenhuollon avohoidon hoitoilmoitus (Avohilmo)" of the Finnish Institute for Health and Welfare are used.
Medication use

Time frame: 1995-2021

Reimbursable drugs from the Social Insurance Institution of Finland (SII). Finnish residents are covered under the National Health Insurance (NHI) scheme run by the SII. SII maintains a nationwide registry of all patients, with dispensed reimbursable drugs 1995-, including opioids and neuropathic pain medications. Data of medication use, cost, and reimbursement data are gathered from the SII database.
Causes of death

Time frame: 2010-2021

Causes of death from Statistics Finland. Statistics Finland maintains a registry of causes of death and death certificates, which are supplemented with data from the population information system of the Population Register Centre. Registry data are used to study excess mortality of the patients.

Sponsors and collaborators

Lead sponsor

Kuopio University Hospital

Other

Registry information

Acronym: DEGERWD

Important dates

Study start: 2022
Primary completion: 2027
Study completion: 2027
First posted: Jan 17, 2024
Registry last updated: Jan 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting