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NCT Number: NCT06327061

Social Network Overdose Prevention and Education Intervention

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs).

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Johns Hopkins Bloomberg School of Public Health

Baltimore, Maryland, 21205, United States

Location status: Recruiting

Location contact

Carl Latkin, PhD

CONTACT

[email protected]

410-955-3972

Carl Latkin, PhD

PRINCIPAL_INVESTIGATOR

About this study

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs). The investigators have utilized PEs for overdose prevention in interventions that have focused on training network members who use drugs to respond to an overdose. Yet, many overdoses are witnessed by people who do not use drugs. Additionally, many PWUO report using drugs at home and living with someone who does not use drugs, which highlights the importance of training non-using network members on overdose response. Based on pilot data, the investigators propose expanding an overdose peer education intervention to focus on non-using network members. The intervention seeks to prepare network members to respond to an overdose and normalize discussions about overdose prevention planning between index PWUO and non-using network members. The intervention condition consists of 3 individual sessions focused on overdose prevention and response. This condition is designed to train index study participants to be Peer Educators. In addition to the three sessions, the non-drug using network member will be offered one session. The control condition is only 1 session focused on overdose prevention and response. Both intervention and control participants will invite social network members to take part in data collection activities

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • self-reported illicit opioid use at least 2 times in the past two weeks;
  • age 18 and older;
  • living in the Baltimore metropolitan region;
  • willing to engage in peer education; and
  • having and willing to recruit at least one non-using network member.

Exclusion criteria

Participants without the cognitive ability to provide informed consent and have the physical ability to participate in in-person intervention sessions.

Treatment and study plan

Network overdose prevention

Behavioral

Participants are taught overdose prevention methods with network members.

Standard of care health education

Behavioral

Participants will receive the standard of care for overdose prevention.

Primary outcomes

  1. Number of drug overdoses

    Time frame: 3-months

    Number of drug overdoses in prior three months

  2. Participant drug use

    Time frame: 3-months

    Proportion of times participants tested positive for drugs of fentanyl and xylazine using test strips in the prior 3 months.

Secondary outcomes

  1. Number of Network member contacts

    Time frame: 3-months

    Number of network members talked to about overdose prevention in prior 3 months

Study contacts

Contact information is provided by the study sponsor or research team.

Carl Latkin, PhD

CONTACT

[email protected]

(410)955-3972

Sponsors and collaborators

Lead sponsor

Johns Hopkins Bloomberg School of Public Health

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

A Social Diffusion Fatal Overdose Prevention Intervention: Assessing the Effectiveness of People Who Use Opioids as Peer Educators in Training Using & Non-using Networks on Overdose & Stigma Reduction

Important dates

Study start
2024
Primary completion
2028
Study completion
2029
First posted
Mar 25, 2024
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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