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NCT Number: NCT05320835

A Setting Focus Overdose Prevention Intervention

A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

This is a pilot of an injection setting targeted peer-driven intervention to reduce HIV/HCV transmission and overdose risk behaviors. Participants will be randomized to conditions: 1) Peer education and stocking of semi-public injection settings (SPIS) with risk reduction materials, and the standard of care. Based on their SPIS use, 120 index PWID participants will be selected.

A conceptual model for the intervention: The conceptual model is based on social influence, social network, and social cognitive theory. The prior work delineated social influence mechanisms. It is expected that training and modeling of effective communication skills will increase the occurrence of conversations on HIV/HCV and overdose prevention. These conversations will then alter perceived descriptive and prescriptive social norms of risk behaviors. The prior work is being enhanced by increasing the availability of risk reduction materials as well as the cuing and modeling risk reduction behaviors in risk settings. It has been found that PWID are motivated to conduct peer education; it enhances their status and provides them a prosocial role in the community. It is hypothesized that peer outreach and supply of materials to SPIS will lead to reduced sharing of injection equipment and increased naloxone availability.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Current drug user (opioid use in the prior two weeks)

Exclusion criteria

  • Any mental or physical health impairment that impedes ability to participate

Treatment and study plan

HIV, HCV and overdose prevention

Behavioral

HIV, HCV and overdose prevention

Primary outcomes

  1. Overdose prevention

    Time frame: 6 months

    Frequency of carrying naloxone

  2. HIV/HCV prevention

    Time frame: 6 months

    Frequency of using used cookers

Secondary outcomes

  1. Overdose behaviors

    Time frame: 6 months

    Frequency of testing drugs before using

  2. Overdose behaviors 2

    Time frame: 6 months

    Frequency of talking about overdose prevention

Study contacts

Contact information is provided by the study sponsor or research team.

Carl Latkin, PhD

CONTACT

[email protected]

410-955-3972

Lauren Dayton, PhD

CONTACT

[email protected]

4105025368

Sponsors and collaborators

Lead sponsor

Johns Hopkins Bloomberg School of Public Health

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

A Geospatial Analysis of Hotspots and Targeted Injection Settings Pilot Intervention for HIV Prevention Among People Who Inject Drugs in Baltimore, Maryland

Acronym: Oasis

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Apr 11, 2022
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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