SMCs With LVH Compared to HCM

The goal of this cohort study is to investigate the clinical characteristics of SMCs and to explore the difference in cardiovascular outcomes in comparison to age-, sex-, and admission year-matched HCM patients. The main question it aims to answer is:

* Do patients with SMCs have higher rates of cardiac outcomes? * What risk factors do SMCs patients experience a poor prognosis?

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Syndromic and Metabolic Cardiomyopathy Cardiomyopathies Cardiovascular Diseases Heart Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Fuwai Hospital, Chinese Academy of Medical Sciences

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients who were diagnosed SMCs or HCM. Gene testing and muscle biopsy were used to confirm the diagnosis of SMCs. The diagnose of HCM was according to the 2024 ESC Guidelines of HCM but without evidence of SMCs.
complete baseline data
accessible follow-up data

Exclusion criteria

incomplete baseine data

Treatment and study plan

SMCs

Other

patients with SMCs

Primary outcomes

primary outcome

Time frame: 3 years

a composite of all-cause death, hospitalization for heart failure, myocardial infarction, ischemia or hemorrhagic stroke (excluding transient ischemic attack), other thrombotic events, and modified International Society on Thrombosis and Haemostasis crit

Sponsors and collaborators

Lead sponsor

China National Center for Cardiovascular Diseases

Other Gov

Registry information

Official study title

Patients With Left Ventricular Hypertrophy in Syndromic and Metabolic Cardiomyopathy Compared to Hypertrophic Cardiomyopathy: an Age-sex Matched Cohort Study

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jun 5, 2025
Registry last updated: Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting