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OpenTrials
Completed

NCT Number: NCT03423693

Small Airway Obstruction in Asthma, COPD, ACOS

This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD

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Key information

Conditions

Asthma Asthma-COPD Overlap Syndrome Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Bronchial Diseases COPD Chronic Disease Disease Attributes Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Siriraj Hospital

Bangkok Noi, Bangkok, 10700, Thailand

About this study

The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physician-diagnosed asthma, ACO, and COPD
  • Their spirometric, IOS, lung volume, demographic data and sputum samples are available

Exclusion criteria

  • Concomitant diseases requiring immunosuppressive therapy
  • Being on treatments with NSAIDs, macrolides, statins

Treatment and study plan

No any intervention

Other

No any intervention is applied to any groups in this study

Primary outcomes

  1. Lipoxin A4, ,

    Time frame: 1 day (single time point)

    Lipoxin A4 is measured in sputum supernatants by ELISA

Secondary outcomes

  1. IL-33

    Time frame: 1 day (single time point)

    IL-33 is measured in sputum supernatants by ELISA

  2. Thymic stromal lymphopoietin (TSLP)

    Time frame: 1 day (single time point)

    TSLP is measured in sputum supernatants by ELISA

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Comparative Study on Sputum Anti-inflammatory Mediators in Patients With Asthma or Asthma and COPD Overlap (ACOS) Syndrome, and COPD

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Feb 6, 2018
Registry last updated
Jun 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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