Sleep Disturbances as a Risk Factor in Chronic Kidney Disease

This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

21 year–74 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Mild to Moderate CKD
Healthy controls age and gender matched to CKD subjects
Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion criteria

Diabetes
Current or previous dialysis for more than 1 month
Uncontrolled hypertension
Heart failure
Liver disease
HIV
Hemoglobin < 10.5 g/dl
Treatment with EProcrit, Epogen, or Aranesp
Bone or organ transplant,
Use of immunosuppressive drugs within past 6 months
Current oral contraceptive use
Current pregnancy
Chemotherapy for malignancy within past 2 years

Treatment and study plan

Controls Short sleep

Other

Healthy control subject's bedtime will be decreased by 2 hours/night with acoustic sleep disruption

Other names: Sleep intervention

CKD- sleep extension

Other

Sleep will be increased by 2 hours each night for 3 nights

Other names: Sleep intervention

Primary outcomes

Comparison of chronobiological profiles of renin/aldosterone, sympatho-vagal balance and CV function in CKD subjects to controls at baseline and after extended sleep in CKD subjects and after decreased time and quality of sleep in control subjects.

Time frame: Immediately after intervention.

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Official study title

Sleep Disturbance as a Non-Traditional Risk Factor in CKD

Acronym: CRIC

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Jan 6, 2009
Registry last updated: Sep 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed