Skeletal Muscles, Myokines and Glucose Metabolism MYOGLU

Inclusion criteria

• Male
• Age 40-65 years
• Nordic ethnicity
• Non-smoker

• Either (participants with impaired glucose metabolism): Body Mass Index (BMI) 27-32 kg/m2 and abnormal glucose metabolism, defined as:

i. impaired fasting glucose (FPG ≥ 5.6 mmol/L) ii. impaired glucose tolerance (2 h PG ≥7.8 mmol/L) iii. type 2 diabetes (no medication, HbA1c ≤7.5%)

• Or (controls): BMI 19-25 kg/m2 and normal glucose metabolism and no first degree relatives with type 2 diabetes.

Exclusion criteria

• Subjects having type 1 diabetes or medically treated type 2 diabetes.
• Systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 90 mmHg at screening
• Significant hematological or renal disease or chronic renal impairment, GFR< 50 ml/min.
• Significant liver disease or ALAT >3x UNL.
• Chronic inflammatory disease in active phase or long-term use of corticosteroids last 3 months.
• Use of anti-diabetic agents, lipid lowering drugs, antihypertensive medication, ASA or any other drug not deemed suitable by the study physician.
• Mental condition (psychiatric or organic cerebral disease), drug or alcohol abuse rendering the subject unable to understand the nature, scope and possible consequences of the study.
• BMI outside inclusion criteria.
• Smoker
• Any medical or other condition that in the judgment of the investigator would jeopardize the subject's safety or evaluation of the intervention for efficacy and safety
• Exercising regularly (>1 times pr week)