Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents

This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Guided by Kirkpatrick's evaluation model, the study investigates improvements in knowledge, technical and non-technical skills, and the retention of these competencies one month after training

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Key information

Conditions

Education Questionnaires

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Selcuk Universitesi, School of Medicine, Anesthesiology

Konya, 42250, Turkey (Türkiye)

About this study

Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication of regional anesthesia. Advances in ultrasound-guided blocks have reduced its incidence, yet LAST remains a major concern due to severe cardiovascular and neurological risks. The American Society of Regional Anesthesia and Pain Medicine (ASRA) recommends early lipid emulsion therapy and emphasizes proper training. Simulation-based multidisciplinary training provides a dynamic and immersive experience, improving both technical and behavioral skills. This trial applies Kirkpatrick's four-level model (reaction, learning, behavior, results) to assess the training program. Primary endpoint: improvement in knowledge test scores. Secondary endpoints: OSCE performance, satisfaction, and key performance indicators related to simulated LAST management.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Surgical residents (General Surgery, Orthopedics, Obstetrics & Gynecology, Dentistry) on active rotation at Selçuk University Faculty of Medicine.
Voluntary participation with written informed consent.
No prior comprehensive LAST training in the last 12 months.

Exclusion criteria

Prior comprehensive LAST training or instructor experience in the last 12 months.
Anesthesiology residents or specialists.
Unable to complete follow-up due to rotation change or leave.
Declining or withdrawing consent.

Treatment and study plan

Education

Behavioral

Local Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training

Primary outcomes

Knowledge improvement (Learning outcome)

Time frame: Baseline (Day 0) to immediately post-training.

Local Anesthetic Systemic Toxicity (LAST) Knowledge Level and Awareness Test Change in 25-item multiple-choice test score (Δ = post-test - pre-test) Scoring: 0-25. It is accepted that as the score obtained for the test increases, the level of knowledge about the subject increases.

Sponsors and collaborators

Lead sponsor

Selcuk University

Other

Registry information

Official study title

Evaluation of the Effectiveness of a Local Anesthetic Systemic Toxicity (LAST) Knowledge Training Program for Non-Anesthesiologist Surgical Residents

Acronym: LAST

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Mar 11, 2026
Registry last updated: Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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