Shunt Evaluation With ALPE System in Thoracic Surgery

. The aim of this study, thus, is to evaluate shunt fraction and markers of alveolar distress during one lung ventilation (OLV) at different levels of positive end expiratory pressure (PEEP). Moreover, investigators will focus on predicting factors of high shunt levels during OLV.

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Key information

Conditions

Mechanical Ventilation Respiratory Tract Diseases Thoracic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Azienda Ospedaliero Universitaria Sant'Anna

Ferrara, 44121, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients scheduled for thoracoscopic lobectomy or thoracoscopic wedge resection in lateral decubitus.
patients American Society of Anesthesiologists Physical Status Classiﬁcation score of 1-3

Exclusion criteria

Patients with hemodynamic instability,
Patients with severe chronic respiratory failure
Patients with preoperative anemia (hemoglobin <10 g 100 ml-1)
Patients requiring unplanned conversion to thoracotomy

Treatment and study plan

Primary outcomes

Pulmonary shunt evaluated with ALPE system

Time frame: every 30 minutes after the start of surgery up to 3 evaluations, up to 90 minutes

Secondary outcomes

predictors of high intraoperative shunt

Time frame: The outcome is assessed 15 minutes after one lung ventilation

All patients admitted to the study received a preoperative physiologic assessment with a cardiovascular evaluation and spirometry. After 15 minutes of one lung ventilation, the pulmonary shunt is evaluated. Therefore, all clinical variable evaluated during preoperative assessment will be compared with the pulmonary shunt

Sponsors and collaborators

Lead sponsor

Università degli Studi di Ferrara

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2016
First posted: Nov 18, 2016
Registry last updated: Mar 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed