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Completed

NCT Number: NCT04321499

SHOX2_PTGER4 DNA Methlyation in Lung Cancer

Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis.

In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a control group of patients with a nodule and ruled out diagnosis of lung cancer will be included.

SHOX2 and PTGER4 will be analyzed via PCR.

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Key information

Conditions

Lungcancer

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ruhrlandklinik, Department of Interventional Pneumology

Essen, North Rhine-Westphalia, 45239, Germany

About this study

Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis.

In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a control group of patients with a nodule and ruled out diagnosis of lung cancer will be included.

A total of 150 patients will be enrolled in this study. SHOX2 and PTGER4 will be analyzed via PCR of blood plasma samples.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

suspicious finding for lung cancer on CT-scan

Exclusion criteria

  • history significant for former malignant diseases

Treatment and study plan

lung cancer

Genetic

PCR for SHOX2 and PTGER4

Primary outcomes

  1. DNA Methylation at early stages of lung cancer

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

University Hospital, Essen

Other

Registry information

Official study title

Establishing a Non-invasive Diagnostic Biomarker Test for Early Diagnosis of Lung Cancer

Acronym: Epi1

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Mar 25, 2020
Registry last updated
Mar 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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