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Completed

NCT Number: NCT03020251

Effects of Preoperative Rehabilitation in Patients Resected for Lung Cancer

This randomized controlled trial will evaluate the effect of a preoperative rehabilitation program at home in patients resected for lung cancer, comparing a control group (C group) receiving only chest physiotherapy and a rehabilitation group (R group) receiving both a training program at home and chest physiotherapy

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Key information

Conditions

Lungcancer

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Clermont Ferrand, Gabriel Montpied, service de médecine du sport et explorations fonctionnelles,, Clermont-Ferrand, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed for lung cancer (or highly suspicious for cancer tumor) eligible for resection surgery (lobectomy or pneumonectomy)
  • Age > 18 years
  • Presence of Chronic Obstructive Pulmonary Disease (COPD) stages 2-4 of Gold (forced expiratory volume (FEV )/ forced vital capacity (FVC) <70%, FEV <80% of predicted) and Exertional dyspnea stage MMRC (Medical Research Council) > 1
  • Patients must provide written consent
  • Member of social security scheme

Exclusion criteria

  • Patients refusing to participate
  • COPD stage 1 Gold (VEMS >= 80% of the theoretical value)
  • Presenting an operating contraindication during the initial maximal exercise test
  • Presenting cardiac or vascular contraindication to achieve the readaptation program
  • Patient living alone at home
  • Patient with ventilatory assistance at home (oxygen therapy or noninvasive ventilation (NIV))
  • With exercise hypoventilation (PaCO2 >45 mmHg)
  • Cognitive difficulty
  • unable major
  • pregnancy,
  • patients deprived of liberty by a court or administrative decision

Treatment and study plan

preoperative chest physiotherapy

Other

preoperative chest physiotherapy : 5 sessions per week during 3 weeks

preoperative rehabilitation program

Other

exercise training at home : 5 sessions per week during 3 weeks

Primary outcomes

  1. Hospital length of stay after resection for lung cancer

    Time frame: time from the date of the surgery (Day 0) until the date of discharge (Day n) (assessed up to 56 days)

    the date of discharge will be the real day of discharge from surgery department or the day where the patient will be medically considered as outgoing

Secondary outcomes

  1. the number of complications

    Time frame: during the stay in the surgery department or the intensive care unit (up to 56 days)

  2. peak oxygen consumption

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)

    evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).

    evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)

  3. 6 minutes walking distance

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)

    evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).

    evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)

  4. maximal voluntary quadriceps strength

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)

    evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).

    evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)

  5. maximal inspiratory and expiratory strength

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)

    evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).

    evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)

  6. real length of stay

    Time frame: between the first postoperative day (Day 1) and the real discharge date (up to 56 days)

    the real day of discharge from surgery department

  7. body composition (bioimpedancemetry)

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)

    evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).

    evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)

  8. oxidative adaptations of the muscle

    Time frame: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2 after intervention : at the date of surgery (during the surgical time at Day 0 week 6)

    optional ancillary study on quadricipal and intercostal muscle biopsies.

Sponsors and collaborators

Lead sponsor

Centre Jean Perrin

Other

Registry information

Acronym: Rexochir

Important dates

Study start
2017
Primary completion
2026
Study completion
2026
First posted
Jan 13, 2017
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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