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Completed

NCT Number: NCT05123794

Shortened Depression Assessment Study

Participants will be asked to fill out an online questionnaire about their demographics information and all 42 items from the Depression Anxiety Stress Scale (DASS-42). A series of machine learning techniques will be applied to the dataset to develop a shortened assessment using the most important demographics and DASS-42 items from the original questionnaire, to predict depression levels indicated by DASS-42.

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Key information

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Toronto

Toronto, Ontario, Canada

About this study

Clinical depression affects 5-10% of the world population each year and is a serious mental health issue globally. There are many traditional psychological scales that assess levels of depression in adults, where their items are often redundant in the information they carry, and their scoring is not necessarily linear to the item scores. Thus, machine learning techniques can help find the redundancy in the items, as well as the nonlinear relationship between the item scores and the final prediction. Using the Depression Anxiety Stress Scale 42 (DASS-42) as the basis, participants will be asked to fill out an online questionnaire about their demographics information (age, gender, country of residence, race, etc.) and all 42 items of DASS-42 to provide a dataset for this study. Feature selection techniques such as MRMR and Gini feature importance were applied to identify the most important features in the dataset. Then, using machine learning methods such as Logistic Regression, XGBoost, and Ensemble models, models will be fitted on the most important features to develop a shortened depression scale (7-9 items consisting of demographics items and DASS items) that accurately predicted the levels of depression (as measured by the AUC, ROC and F1 scores.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 and above
  • Must be able to read English
  • Must have access to the Internet worldwide

Exclusion criteria

  • Children aged 17 and under
  • Persons who cannot read English
  • Persons that do not have access to Internet

Treatment and study plan

Primary outcomes

  1. Rapid Depression Assessment Tool based on Depression Anxiety Stress Scale 42

    Time frame: All participants completed the same assessments, which took 10-15 minutes

    Participants filled out an online questionnaire about their demographic information (age, sex, and ethnicity) and all 42 items from the Depression Anxiety Stress Scale (DASS-42). Each item consists of a 4-point Likert scale from 0 to 3, where 0 means "Did not apply to me at all" and 3 means "Applied to me very much, or most of the time". The depression score is the sum of scores for the items in the depression sub-scale. A higher score indicates a more severe level of depression symptoms.

    Machine learning techniques were used to develop a shortened assessment (Rapid Depression Assessment Tool) using demographics and 5 DASS-42 items from the original questionnaire, to predict severity levels of depression indicated by DASS-42. The assessment tool calculates the likelihood of moderate depression symptoms and severe depression symptoms given the responses from each item (ranging from 0 to 3). The data was collected and aggregated through a public website.

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Registry information

Official study title

Using the Long to Short Approach to Develop Rapid Depressions Scales

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Nov 17, 2021
Registry last updated
Dec 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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