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NCT Number: NCT05198492

Short- and Long-term Health Effects of Air Pollution in Poland

The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack of large industry). The aim of the project is to assess the impact of air pollution in Eastern Poland on regional public health.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acute Coronary Syndrome Arrhythmias, Cardiac Atrial Fibrillation Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Ischemic Stroke Kidney Diseases Male Urogenital Diseases Myocardial Ischemia Nervous System Diseases Oxidative Stress Particulate Matter Inhalation Injury Pathologic Processes Pathological Conditions, Signs and Symptoms Pollution; Exposure Stroke Urogenital Diseases Urologic Diseases Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Invasive Cardiology, Medical University of Bialystok

Bialystok, Podlaskie Voivodeship, 15-276, Poland

About this study

The project will be conducted in Eastern Poland - the area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization. On the other hand, the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions. The vast majority of studies on air pollution were conducted in highly polluted areas, in which patients are exposed to moderate and extreme concentrations of pollutants. Taking into consideration the scarce number of surveys from areas with a low level of pollution the investigators intend to analyze the relationship between air pollution and cardiovascular and renal outcomes in Eastern Poland. The examination of the impact of so-called "Polish smog" on mortality and morbidity in the study area is not without significance. It would be the first major study of the impact of this type of pollution on human health.

In the subsequent part of the study, we will evaluate the effects of Polish smog in the entire country.

In light of extant body of literature, the following will be considered as the public health indicators: acute coronary syndromes, episodes of atrial fibrillation, ischemic strokes, kidney disease hospitalizations or emergency room visits, cardiovascular and renal mortality.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Residents from the analyzed area

Exclusion criteria

  • None

Treatment and study plan

Impact of air pollution

Other

To assess the short- and long- term impact of air pollution

Primary outcomes

  1. Number of acute coronary syndromes related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on the number of hospital admissions for acute coronary syndromes.

  2. Number of atrial fibrillation episodes related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on the number of hospital admissions for atrial fibrillation.

  3. Number of hospitalizations due to kidney diseases related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Long- term influence of air pollution on the number of hospital admissions for kidney disease.

  4. Number of hospitalizations due to acute kidney diseases related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Long- term influence of air pollution on the number of hospital admissions for kidney disease.

  5. Number of patients under hemodialysis related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Long- term influence of air pollution on the number of hospital admissions for kidney disease.

  6. Number of ischemic strokes related to the impact of air pollution.

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on the number of hospital admissions for ischemic strokes.

Secondary outcomes

  1. Cardiovascular mortality

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on the number of cardiovascular mortality.

  2. Neoplasm mortality

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on neoplasm mortality.

  3. Kidney disease mortality

    Time frame: Through study completion, an average of 1 year

    Short- and long- term influence of air pollution on mortality related to renal function.

Sponsors and collaborators

Lead sponsor

Medical University of Bialystok

Other

Collaborators

  • Charles University, Czech Republic
  • University of Liverpool
  • University of Lodz
  • University of Skopje

Registry information

Acronym: EP-PARTICLES

Important dates

Study start
2011
Primary completion
2020
Study completion
2030
First posted
Jan 20, 2022
Registry last updated
Jun 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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