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OpenTrials
Completed

NCT Number: NCT05583084

Sex-unique Disparities in Survival and Resuscitation After Out-of-hospital Cardiac Arrest - a Danish Analysis

The goal of this observational study is to investigate characteristics in out-of-hospital cardiac arrests (OHCA) related to sex differences.

The main questions it aims to answer are:

* are there possible differences in help provision by bystanders, cardiopulmonary resuscitation (CPR), pre-hospital treatment by emergency medical services (EMS)? * are there differences in the presence of shockable initial rhythm (SIR) and survival rates after OHCA at successive stages of treatment? Researchers will compare all emergency medical services treated resuscitations in Denmark between 2016 and 2021 to see if there are possible differences between sexes.

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Key information

Conditions

Out-Of-Hospital Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

This analysis will be based on data from the national electronic based Danish OHCA registry. Data on OHCAs with resuscitative attempts in Denmark have been collected in the electronic based Danish Medical Service report system since 2016. The registry covers detailed data including the EMS report, executive entries, and advanced text searches of prehospital charts. All cases go through an elaborate validation process where all identified events are read through manually by an external verification team. This ensures high quality of data, collected according to the Utstein recommendations, throughout the approximately 5400 cases of OHCA in Denmark annually. During this verification process, supplementary sources of data are linked to each OHCA, among others information about survival, localization, initiation of bystander CPR and EMS personnel operation.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All emergency medical services treated resuscitations in Denmark between 2016 and 2021

Exclusion criteria

  • Patients that are found dead at emergency medical service arrival, with sure death indicators such as rigor mortis or livores.

Treatment and study plan

Investigation

Other

Primary outcomes

  1. 30-days survival

    Time frame: 30 days from OHCA

    Records on survival after 30 days from cardiac arrest

Secondary outcomes

  1. Cardiopulmonary Resuscitation (CPR)

    Time frame: 2016-2021

    Whether or not CPR was performed on the patient

  2. Presence of shockable initial rhythm (SIR)

    Time frame: 2016-2021

    Whether or not a schockable intial rhythm was recorded

  3. Return of spontaneous circulation (ROSC) at any time

    Time frame: 2016-2021

    Whether or not there was return of spontaneous circulation at any time

Sponsors and collaborators

Lead sponsor

Prehospital Center, Region Zealand

Other

Registry information

Important dates

Study start
2016
Primary completion
2021
Study completion
2021
First posted
Oct 17, 2022
Registry last updated
Oct 17, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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