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Completed

NCT Number: NCT04237727

CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study

The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS). A portable device capable of detailed measurments of ventilation will be used when ventilating patients suffering cardiac arrest.

The main objective of the study is to describe the ventilatiosn given in terms of volume, frequency and pressure, both overall and during different CPR modes and when using different methods to handle the patients airway.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Regionale Ambulance Voorziening Utrecht, Netherlands, Amersfoort, Utrecht, Netherlands

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About this study

The aim with this observational multicenter study is to measure and describe manual ventilation during cardiopulmonary resuscitation in the advance life support setting.

Primary endpoint is the ventilation quality measured as ventilation frequency, tidal volume, minute ventilation peak inspiratory pressure and exhaled CO2.

This will be studied in both asycnhronous ventilations, meaning ventilations that are given during ongoing chest compressions and syncrhonous ventilations, meaning ventilations given during a pause of the chest compressions, in a 30:2 repeatign pattern. Aditionally, airway modalities such as bag-valve-masks, Supraglottic airway devices and endotracheal tubes will be studied.

The inclusion of patients will be performed at five sites, The Uppsala emergency medical services, Uppsala, Sweden, Capio AB akutläkarbilar (rapid response cars), Stockholm Sweden, Falun County hospital, Falun, Sweden, EMS Amsterdam post West, Amsterdam, The Netherlands and Lifeliner 1 HEMS, Amsterdam, The Netherlands Eligible for inclusion are patients over 18 years old suffering cardiac arrest in the areas served by the including emergency medical systems and in-hospital emergency team.

The goal is to include at least 200 patients.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Out-of-hospital cardiac arrest (OHCA) treated with CPR performed by the EMS personnel

Exclusion criteria

  • Patient age < 18 years
  • Known pregnancy

Treatment and study plan

Fluxmed GrH portable pneumotachograph

Device

Fluxmed GrH portable pneumotachograph is used to measure the given ventilation. It is placed on the chosen airway adjunct and passively measures ventilation parameters such as volumes, and flow.

Primary outcomes

  1. Ventilation frequency

    Time frame: 1 Day

    Measured as ventilations per minute.

  2. Tidal volume

    Time frame: 1 Day

    Measured as milliliters per ventilation.

  3. Minute Ventilation

    Time frame: 1 Day

    Measured as litres per minute.

Secondary outcomes

  1. Variation of etCO2 in relation to different ratios of compression to ventilations

    Time frame: 1 Day

    etCO2 measured as kilopascal for each exhalation during CPR with 30 compressions and 2 ventilations and during continous compressions and ventilations.

  2. Time of inspiration

    Time frame: 1 Day

    Measured as seconds for each inspiration.

  3. Fraction of dead space ventilation

    Time frame: 1 Day

    Dead space measured as milliliters for each ventilation compared to the tidal volume in milliters for that same ventilation.

  4. Peak inspiratory pressure during ventilation

    Time frame: 1 Day

    Measured as cmH20 for each ventilation.

  5. Return of spontaneous circulation

    Time frame: 1 Day

    If the patient, as stated by the ALS provider, has spontaneous circultation during the resuscitation attempt

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Collaborators

  • Amsterdam UMC
  • Capio AB Rapid Response Cars, Stockholm, Sweden
  • Dalarna County Hospital, Falun, Sweden
  • Regionale Ambulance Voorziening, Amersfoort, Utrecht, Netherlands

Registry information

Acronym: CAvent

Important dates

Study start
2019
Primary completion
2025
Study completion
2025
First posted
Jan 23, 2020
Registry last updated
Apr 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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