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OpenTrials
Completed

NCT Number: NCT05256069

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

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Key information

Conditions

Vasodilation Aneurysm Cardiovascular Diseases Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Missouri-Columbia

Columbia, Missouri, 65211, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adult men and women;
  • 18-45 years of age;
  • BMI 18-30 kg/m2;
  • non-pregnant/non-breastfeeding;
  • non-nicotine users;

Exclusion criteria

  • Pregnancy, breastfeeding, hormonal contraceptives
  • Diagnosed sleep apnea
  • Current smoking/Nicotine use/drug use
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications
  • Recent COVID-19 diagnosis with symptoms

Treatment and study plan

Propranolol Pill

Drug

Participants will receive a β-blockade (propranolol pill, 1 mg/kg dosed based on participant weight).

Placebo

Drug

Participants will receive a placebo in pill form.

Primary outcomes

  1. Forearm Blood Flow

    Time frame: Change from baseline to 5 minutes

    Measured with venous occlusion plethysmography (mL/dL/min)

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Collaborators

  • American Heart Association

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Feb 25, 2022
Registry last updated
Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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