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Completed

NCT Number: NCT02096224

Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

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Key information

Conditions

Catheter Site Discomfort Anesthesia Complications Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Neoplasms Neoplasms by Site Urinary Bladder Diseases Urinary Bladder Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University of Hospital

Seoul, South Korea

About this study

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for transurethral bladder excision under general anesthesia
  • ASA I-III

Exclusion criteria

  • Bladder outflow obstruction
  • Overactive bladder
  • End-stage renal disease
  • Neurogenic bladder
  • Heart failure
  • Arrhythmia
  • Morbid obesity
  • Use of chronic analgesic medication
  • Hepatic disease
  • Pulmonary disease
  • Psychiatric disease

Treatment and study plan

Sevoflurane

Drug

Sevoflurane will be used.

Desflurane

Drug

Desflurane will be used

Primary outcomes

  1. Catheter-related bladder discomfort

    Time frame: 24 hour postoperatively

    Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

Secondary outcomes

  1. Catheter-related bladder discomfort

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

  2. Nausea

    Time frame: 0, 1, 6 and 24 hour postoperatively

    The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.

  3. Vomiting

    Time frame: 0, 1, 6 and 24 hour postoperatively

    The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.

  4. Dry mouth

    Time frame: 0 houe after admission of operating room

    Dry mouth after the admission of operating room will be assessed. (score:0-10)

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Mar 26, 2014
Registry last updated
Oct 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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