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Completed

NCT Number: NCT02252445

Propofol and Sevoflurane for Catheter-Related Bladder Discomfort

The investigators want to evaluate the efficacy of the propofol and sevoflurane for the prevention of catheter-related bladder discomfort.

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Key information

Conditions

Catheter Site Discomfort Anesthesia Complications Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Neoplasms Neoplasms by Site Urinary Bladder Diseases Urinary Bladder Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

19 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seolu National University of Hospital

Seoul, South Korea

About this study

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. Propofol and desflurane are most widely used as an anesthetic agent. Propofol and desflurane are known to block the muscarinic receptor in different ways.

The investigators want to evaluate the efficacy of the propofol and sevoflurane for the prevention of catheter-related bladder discomfort.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for transurethral bladder excision under general anesthesia
  • ASA I-III

Exclusion criteria

  • Foley catheter less than 18 Fr.
  • Patients with obstruction of urinary tract
  • Patients with neurogenic bladder
  • Patients with severe obesity
  • Patients with neurologic disorder
  • Patients with chronic pain
  • Patients with allergic history to propofol or sevoflurane

Treatment and study plan

Propofol

Drug

Propofol will be administered.

Sevoflurane

Drug

Sevoflurane will be administered.

Primary outcomes

  1. Catheter-related Bladder Discomfort

    Time frame: 1 hour postoperatively

    Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). Patients with score >0 will be counted.

Secondary outcomes

  1. Catheter-related Bladder Discomfort

    Time frame: 0, 6 and 24 hour postoperatively

    Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). Patients with score >0 will be counted.

  2. Hemodynamic Parameters

    Time frame: 0, 1, 5, 10 minute postoperatively

    Mean blood pressure and heart rate will be measured at 0, 1, 5, 10 minute postoperatively. Measurement at 10 minute means Mean blood pressure and heart rate at the admission of post-anesthetic care unit.

  3. Nausea

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Nausea will be measured at 0, 1, 6 and 24 hour postoperatively.

  4. Vomiting

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Vomiting will be measured at 0, 1, 6 and 24 hour postoperatively.

  5. Dry Mouth

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Dry mouth will be measured at 0, 1, 6 and 24 hour postoperatively.

  6. Flushing

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Flushing will be measured at 0, 1, 6 and 24 hour postoperatively.

  7. Blurred Vision

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Blurred vision will be measured at 0, 1, 6 and 24 hour postoperatively.

  8. Dizziness

    Time frame: 0, 1, 6 and 24 hour postoperatively

    Dizziness will be measured at 0, 1, 6 and 24 hour postoperatively.

  9. Analgesics

    Time frame: 0, 1, 6 and 24 hour postoperatively

    The amount of analgesics will be measured at 0, 1, 6 and 24 hour postoperatively.

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Effect of Propofol and Sevoflurane on Postoperative Catheter-Related Bladder Discomfort

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Sep 30, 2014
Registry last updated
Sep 1, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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