Serum CPK and Creatinine Changes During Plyometric Training in Collegiate Athletes

This study evaluated the physiological effects and safety of an eight-week lower body plyometric training program in male collegiate volleyball players, focusing on changes in serum creatine phosphokinase (CPK) and creatinine levels. Sixty two healthy athletes were randomly assigned to either a plyometric training group or a control group. The experimental group performed progressive lower body plyometric exercises twice weekly for eight weeks, while the control group continued regular volleyball training.

Serum CPK and creatinine were assessed at baseline and multiple time points throughout the intervention. CPK levels in the training group increased significantly early in the program, peaking on Day 4 and remaining elevated until Week 2, before returning to baseline by Week 8. Importantly, all values remained within normal clinical ranges, and no signs of rhabdomyolysis or overtraining were observed. Serum creatinine levels showed no significant changes, indicating preserved renal function. No biomarker changes were detected in the control group.

These findings indicate that an eight-week, progressively designed plyometric training program is safe and well tolerated in male collegiate volleyball players.

Inclusion criteria

• male collegiate volleyball players
• Age: 18-20 years
• No prior plyometric training

Exclusion criteria

• History of kidney disease
• Current musculoskeletal injury
• neuromuscular impairments