Sensory Processing in Subjects With Painful Bladder Syndrome

The purpose of this study is to determine if clinically relevant subsets exist in patients meeting the diagnosis of Painful Bladder Syndrome (PBS). Subsets suggest differential responses to treatments and if verified, this will be important for the stratification of patients in clinical studies related to PBS.

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Key information

Conditions

Painful Bladder Syndrome Cystitis Cystitis, Interstitial Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Urinary Bladder Diseases Urogenital Diseases Urologic Diseases

Age range

19 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kirklin Clinic Urology Clinic

Birmingham, Alabama, 35294, United States

About this study

Patients with the diagnosis of painful bladder syndrome (PBS) constitute two or more phenotypes that are distinguished by differential neurophysiological processing of sensory information. Further, these differing phenotypes can be predicted by the presence or absence of the co-morbidity fibromyalgia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

NIDDK criteria for Painful Bladder Syndrome
Age 19 years or older
Must be able to read and speak English since testing materials are validated in English

Exclusion criteria

PBS subjects must be independent of co-existing pain disorders or use of medications
Uncontrolled hypertension or significant cardiopulmonary disease
No chronic daily pain
Older than 75 years of age

Treatment and study plan

physical examination

Other

Physical examination and multiple questionnaires will be administered

Primary outcomes

This study proposes to examine the sensations that are produced by warming the skin, poking the skin, pressure on muscles and by applying a blood pressure cuff.

Time frame: One and half to two hours.

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

Washington University Early Recognition Center

Registry information

Important dates

Study start: 2008
Primary completion: 2014
Study completion: 2014
First posted: May 18, 2009
Registry last updated: Jul 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed