Sedation and Ease of Weaning From Mechanical Ventilation

Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

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Key information

Conditions

Respiratory Failure Chronic Disease Chronic Obstructive Pulmonary Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Midazolam Overdose Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases Weaning Failure

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Emad Zarief Kamel Said

Asyut, 71111, Egypt

About this study

there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Obstructive lung disease
Respiratory failure
Invasive mechanical ventilation

Exclusion criteria

Neurological deficit
Cognitive dysfunction
Extensive malignancy
septic Shock

Treatment and study plan

Daily interruption of midazolam

Drug

daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done

Other names: sedation interruption

Primary outcomes

duration of mechanical ventilation

Time frame: first 30 days

number of days of mechanical ventilation

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Daily Interruption of Sedation Versus Non Sedation in Mechanically Ventilated Respiratory Failure Patients

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Jan 23, 2018
Registry last updated: Jan 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed