Secretin in Refeeding

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Recruiting

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Key information

Conditions

Anorexia in Adolescence

Age range

13 year–24 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California, Los Angeles (UCLA)

Los Angeles, California, 90095, United States

Location status: Recruiting

Location contact

Finnegan Mercer

CONTACT

[email protected]

310-206-7631

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group 1:

male and female patients
age 13-24 years
diagnosis of restrictive-type anorexia nervosa
hospitalization for nutritional support
>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
Group 2:

male and female patients
age 13-24 years
diagnosis of restrictive-type anorexia nervosa
hospitalization for nutritional support
<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Exclusion criteria

5150 hold
Anti-depressant, anti-psychotic, or anticonvulsant medications
Previous hospitalization within the past 6 months
Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
Pregnancy
NG or G-tube feeds after day 2 of hospitalization
> 10% of nutritional needs from supplemental feeds

Treatment and study plan

Primary outcomes

Change in secretin

Time frame: 1 hour

Change in secretin value from pre- to post- meal

Secondary outcomes

Change in serum bicarbonate

Time frame: 1 hour

Change in bicarbonate value from pre- to post- meal

Study contacts

Contact information is provided by the study sponsor or research team.

Misciel Macaraig

CONTACT

[email protected]

310-825-0922

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Registry information

Official study title

Secretin Levels in Refeeding-induced Polyuria (Cross Section)

Important dates

Study start: 2022
Primary completion: 2027
Study completion: 2027
First posted: Feb 11, 2022
Registry last updated: Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting