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Completed

NCT Number: NCT02473484

Search of Protein Biomarkers in Order to Achieve a Molecular Classification of Gliomas

The aim is to classify high grade glioma by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI). In order to provide more specific informations for the diagnosis and the prognosis of high grade glioma.

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Key information

Conditions

Glioblastoma Astrocytoma Glioma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Le Rhun

Lille, 59000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Main inclusion criteria:

  • Patients with grade III or IV glioma newly diagnosed with histological evidence
  • Surgical indication
  • Tumor tissue available at biobank of Lille
  • Men and women aged ≥ 18 years
  • Informed Consent signed by the patient or his legal representative.

Main exclusion criteria:

  • Antecedents of other cancers except basal cell skin cancer or carcinoma in situ of the uterus cervix
  • Previous history of brain radiotherapy
  • Anti-tumor systemic treatments (chemotherapy or targeted therapy) prior to surgery of glioma
  • Genetic disease that may cause brain tumor, potentially radiation-induced tumor
  • History of degenerative neurological disease prior to diagnosis
  • contraindication to MRI

Treatment and study plan

Primary outcomes

  1. To evaluate the correlation between the WHO classification 2007 only established standard diagnostic and classification by mass spectrometry gliomas (lipids, peptides, proteins)

    Time frame: 2.5 years

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Acronym: GLIOMIC

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Jun 16, 2015
Registry last updated
Dec 22, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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