Screening for Bleeding Disorders in Children

Objective : To determine simple clinical and biological factors that can improve the screening of hemostatic diseases at risk of hemorrhage in children.

Method:

• Retrospective inclusion of all patients <18 years referred to the CRTH in pediatric consultation for the reason of exploration of a hemorrhagic syndrome or exploration of an anomaly in the hemostasis assessment.
• Data collected (by collection in the medical file):

Patient data: Age, sex, personal and family history of hemorrhagic disease

Clinical data: hemorrhagic symptomatology (epistaxis, gingivorrhagia, etc.) Biological data: PT, TCK, factor assay, platelet function Medical data: complete diagnosis if diagnosis of hemorrhagic disease

• Scores: HEMOSTOP, PBQ, ISTH, TOSETTO score
• Analyzes: calculation of the Odd Ratio, AUC, Se, Sp, VPP, VPN for different clinical / biological factors and each score.

Inclusion criteria

• referred by their general practitioner or another caring physician for evaluation of bleeding symptoms
• abnormal laboratory test results or family study
• the patient being the first-degree relative of a patient with a known bleeding disorder.

Exclusion criteria

• older than 18 years old.