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NCT Number: NCT01194024

Scoring System for Inhalation Injury

The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy

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Key information

Conditions

Inhalation Injury Burns Burns, Inhalation Smoke Inhalation Injury Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Arizona Burn Center, Maricopa Integrated Health Systems, Phoenix, Arizona, United States

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About this study

The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Injury consistent with inhalation of smoke or products of combustion
  • Requires intubation within 24 hours of injury
  • Meets one of the following 4 criteria
  • history of closed space injury
  • carbonaceous sputum
  • elevated carboxyhemoglobin
  • dx of inhalation injury is considered likely by investigator

Exclusion criteria

  • ≤ 17 years of age
  • Prisoner

Treatment and study plan

Standard of care

Other

bronchoscopy with collection of bronchioalveolar lavage specimen, blood samples, High-Resolution spiral computed tomography(CT)

Primary outcomes

  1. Development of a diagnostic model to predict the severity of inhalation injury

    Time frame: within 48 hours of admission

    The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers.

Secondary outcomes

  1. Impact of inhalation injury

    Time frame: at discharge

    Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI).

Sponsors and collaborators

Lead sponsor

American Burn Association

Other

Collaborators

  • U.S. Army Medical Research and Development Command

Registry information

Official study title

Burn Multicenter Proposal: Development of an Inhalation Injury Scoring System to Predict Severity of Inhalation Injury

Important dates

Study start
2011
Primary completion
2019
Study completion
2019
First posted
Sep 2, 2010
Registry last updated
Jul 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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