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Completed

NCT Number: NCT06561282

Predictive Role of Glucose/Potassium Ratio on Mortality in Major Burns.

The aim of this observational study is to investigate the role of the glucose-potassium ratio in predicting mortality in patients with major burn trauma.

The main question it aims to answer is: Can the glucose-potassium ratio predict mortality in major burn patients? The glucose-to-potassium ratios of major burn patients at the time of initial hospitalization will be determined, and their relationship with mortality will be analyzed.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Konya Training and Research Hospital

Konya, 42090, Turkey (Türkiye)

About this study

Major burns, especially electrical burns, facial burns, inhalation burns, burns with large burn surface areas, and deep burns, have a high mortality risk. Early detection of this risk may be critical to reducing mortality rates. For this reason, trauma centers are working on rapid and effective prognostic markers. In trauma and stress situations, glucose levels rise while potassium levels fall due to increased catecholamines. The literature reports that hyperglycemia, also known as the glucose-potassium ratio, can rapidly and effectively predict morbidity and mortality in patients suffering from subarachnoid hemorrhage, pulmonary embolism, traumatic brain injury, or blunt abdominal trauma. Many publications show that increased glucose is associated with mortality and morbidity in critical illnesses and trauma. The isolated glucose-potassium ratio has a higher predictive ability for mortality and morbidity compared to glucose and potassium levels. In this study, investigators aimed to examine the prognostic value of the glucose-to-potassium ratio in participants with major burn trauma.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All burns >40% of total body surface area (2nd degree or deeper)
  • Burns with inhalation injury
  • Burns >20% of total body surface area 3nd degree or deeper

Exclusion criteria

  • First degree burns
  • Patients have more than 24 hours since the onset of burn trauma
  • Patients with diabetes mellitus
  • Patients with chronic renal failure
  • Patients taking potassium-modifying medication
  • Patients with missing data

Treatment and study plan

Primary outcomes

  1. Glucose-to-potassium ratio

    Time frame: 2 days

    The glucose-to-potassium ratio is calculated by dividing the participants' glucose values when they first apply to the hospital by their potassium values.

Secondary outcomes

  1. Female/Male ratio

    Time frame: 2 days

    It is calculated by dividing the number of females by the number of males in the study population.

  2. Mean percent of total body surface area burned

    Time frame: 2 days

    It is calculated by adding the total burn surface area percentage values of all patients and dividing by the number of participants.

  3. Burn infection rate

    Time frame: 2 days

    The number of patients developing burn infection is calculated by dividing by the number of all participants.

  4. Mortality rate

    Time frame: 2 days

    The mortality rate is calculated by dividing the number of patients who developed mortality by the number of all participants.

Sponsors and collaborators

Lead sponsor

Konya Meram State Hospital

Other

Registry information

Official study title

The Predictive Role of Glucose/Potassium Ratio for Mortality in Patients With Major Burn Trauma

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Aug 20, 2024
Registry last updated
Aug 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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