Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children

The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out a complete survey about smoking habits. After filling out the questionnaire, according to the survey results, a total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalance of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' which are expected to increase in passive smoking group; 'antimicrobial peptide LL-37' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.

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Key information

Conditions

Passive Smoking Children Dental Caries Oxidative Stress Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

6 year–12 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-Systemically healthy children

Exclusion criteria

The presence of orthodontic / intraoral appliance
Any disease or condition known to affect defense system
Uncooperative children

Treatment and study plan

taking saliva samples to determine TAS, TOS and LL-37

Diagnostic Test

Primary outcomes

salivary oxidative stress values: TAS level

Time frame: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.
salivary oxidative stress values: TOS level

Time frame: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.
salivary LL-37 level

Time frame: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.
salivary cotinine levels

Time frame: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children for describing passive smoking children.

Sponsors and collaborators

Lead sponsor

Merve Erkmen Almaz

Other

Collaborators

Kırıkkale University

Registry information

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Mar 3, 2020
Registry last updated: Mar 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed