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OpenTrials
Completed

NCT Number: NCT02913248

Salivary Bacterial Profiles in Relation to Periodontal Treatment

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

40 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Copenhagen, Department of Odontology

Copenhagen, 2200, Denmark

About this study

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Manifest chronic periodontitis according to international classification

Exclusion criteria

  • Other treatment requiring oral conditions
  • Systemic antibiotics within the latest 6 months
  • Systemic diseases and medications with known associations to periodontitis
  • Pregnancy and breastfeeding

Treatment and study plan

Conventional periodontal treatment

Procedure

Non-surgical periodontal treatment including thorough instruction in self-performed oral hygiene

Primary outcomes

  1. Changes in α-diversity in saliva samples collected .

    Time frame: Baseline and 12 weeks

    Comparison of α-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment

Secondary outcomes

  1. Specis specific changes in saliva samples collected

    Time frame: Baseline and 12 weeks

    Comparison of relative abundance of bacterial species in saliva samples collected before periodontal treatment to samples collected 12 weeks after treatment

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • Rigshospitalet, Denmark
  • The Forsyth Institute

Registry information

Official study title

Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Sep 23, 2016
Registry last updated
Feb 3, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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