Skip to main content
OpenTrials
Completed

NCT Number: NCT05135286

Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Presbyopia Eye Diseases Refractive Errors

Age range

45 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Visus Therapeutics Investigative Site, Chandler, Arizona, United States

Loading trial locations.

About this study

Multicenter, Double-Masked, Randomized, Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF Topical Ophthalmic Solution With Emmetropic Phakic and Pseudophakic Presbyopia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female in good general health
  • Must have presbyopia

Exclusion criteria

  • History of allergic reaction to the study drug or any of its components
  • Any disease or medical condition that, in the opinion of the Investigator, would prevent the subject from participating in the study or might confound study results

Treatment and study plan

BRIMOCHOL™ PF

Drug

A single drop in each eye at a visit.

Other names: carbachol/brimonidine tartrate

Carbachol PF

Drug

A single drop in each eye at a visit.

Other names: carbachol monotherapy

Vehicle

Drug

A single drop in each eye at a visit.

Primary outcomes

  1. Change from baseline in near VA

    Time frame: Baseline Day 1

    Percentage of subjects with 3-line improvement in near VA without the loss of at least 1 line in distance VA

Sponsors and collaborators

Lead sponsor

Visus Therapeutics

Other

Registry information

Official study title

Multicenter, Double-Masked, Randomized, Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF Topical Ophthalmic Solution With Emmetropic Phakic and Pseudophakic Presbyopia

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Nov 26, 2021
Registry last updated
Aug 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.