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NCT Number: NCT03244072

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis

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Key information

Conditions

Endophthalmitis Eye Diseases Eye Infections Infections

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Zion Eye Institute

St. George, Utah, 84790, United States

Location contact

Jason Ahee, M.D.

CONTACT

About this study

Subjects will receive either intracameral injection of 0.1% moxifloxacin solution or placebo after cataract surgery. They will be followed for one month to determine if there is a statistically significant difference in the incidence of endophthalmitis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • visually significant cataracts

Exclusion criteria

  • allergy to fluoroquinolones, cobalamin (B12)

Treatment and study plan

moxifloxacin

Drug

Intracameral injection

Other names: active

Placebo

Drug

intracameral injection

Other names: sham

Primary outcomes

  1. Endophthalmitis after cataract surgery

    Time frame: Subjects will undergo eye examinations at one day, one week, and one month post-operatively

    Subjects will be followed after cataract surgery and have post-operative eye examinations to determine if infection in the eye (endophthalmitis) occurs during the study period.

Study contacts

Contact information is provided by the study sponsor or research team.

Jason Ahee, M.D.

CONTACT

[email protected]

435-862-9865

Sponsors and collaborators

Lead sponsor

Jason Ahee, M.D.

Industry

Registry information

Official study title

Safety and Efficacy of Intracameral Zimoxin (0.1% Moxifloxacin Solution) for Prevention of Endophthalmitis After Cataract Surgery

Important dates

Study start
2026
Primary completion
2030
Study completion
2031
First posted
Aug 9, 2017
Registry last updated
Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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