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NCT Number: NCT05061784

Routine Transcervical Thymectomy in MEN-1 Patients

A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

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Key information

Conditions

Multiple Endocrine Neoplasia Type 1 (MEN-1) Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endocrine Gland Neoplasms Endocrine System Diseases Genetic Diseases, Inborn Multiple Endocrine Neoplasia Multiple Endocrine Neoplasia Type 1 Neoplasms Neoplasms by Site Neoplasms, Multiple Primary Neoplastic Syndromes, Hereditary Thymic Carcinoid

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National University Hospital

Singapore

About this study

Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients.

Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Studies including MEN-1 patients who underwent a routine thymectomy during parathyoidectomy
  • We accepted randomized controlled trials or observational studies that included patients of any age who underwent a routine TCT in the setting for MEN-1, published as full-length articles in peer-reviewed journals, which mentioned data on thymic carcinoid tumours.

Exclusion criteria

  • We excluded reviews, letters, conference proceedings and non-English publications.

Treatment and study plan

Routine thymectomy, which has been performed

Procedure

There is no intervention

Primary outcomes

  1. Incidence of thyme carcinoid

    Time frame: The timeframe will be from date of transcervical thymectomy until the date of documented diagnosis of diagnosis of thymic NET; progression of disease or date of death from any cause, whichever came first, assessed up to 100 months.

    Retrospective review of published studies

Sponsors and collaborators

Lead sponsor

National University Health System, Singapore

Other

Registry information

Official study title

Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention of Thymic Carcinoid Tumours in MEN-1 Patients a Case Series

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Sep 30, 2021
Registry last updated
Sep 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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