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OpenTrials
Completed

NCT Number: NCT07352124

Rosemary Infusion for Hypertension With Hypertriglyceridemia

This study aimed to evaluate the effects of daily rosemary infusion consumption on blood pressure and lipid profile in patients with mild hypertension, stratified by triglyceride status.

This 6-week open-label interventional study enrolled 47 patients with mild hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHg). Participants were stratified into two groups: normal triglycerides, TG <1.7 mmol/L, n=22 and high triglycerides, TG ≥1.7 mmol/L, n=25. Blood pressure was assessed using 24-hour ambulatory monitoring (Holter) at baseline and day 45. Comprehensive biochemical analysis included lipid profile, hepatic and renal function markers, and inflammatory parameters.

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Key information

Conditions

Hypertension With Hypertriglyceridemia Cardiovascular Diseases Dyslipidemias Hyperlipidemias Hypertension Hypertriglyceridemia Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sassi

Sousse, 4023, Tunisia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants of both sexes, aged 18 years and older, were included in the study. The inclusion criteria were: (1) Presence of mild hypertension defined as systolic blood pressure (SBP) of 140-159 mmHg and/or diastolic blood pressure (DBP) of 90-99 mmHg according to the 2018 ESC/ESH guidelines(Williams et al., 2018); (2) No use of medications or dietary supplements for other health conditions.

Exclusion criteria

Participants were excluded if they had renal failure, autoimmune diseases, major gastrointestinal disorders, or a history of cardiovascular disease. Other exclusion criteria included current or past use of medications known or suspected to influence blood pressure or metabolic parameters

Treatment and study plan

Rosemary infusion

Dietary Supplement

Rosemary infusion 100 ml during 45 days

Primary outcomes

  1. Blood pressure measurement

    Time frame: 45 days

  2. Evolution of serum triglycerides

    Time frame: 45 days

Secondary outcomes

  1. Cardiovascular disease risk assessment

    Time frame: 45 days

  2. Atherogenic Index of Plasma

    Time frame: 45 days

Sponsors and collaborators

Lead sponsor

awatef Sassi

Other

Registry information

Official study title

Rosemary Infusion for Hypertension With Hypertriglyceridemia: A Triglyceride-Stratified Clinical Study

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 20, 2026
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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