Role of Wound Irrigation After Appendectomy

Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection. The present trial aims to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution in prevention of superficial surgical site infection after open appendectomy for acute uncomplicated appendicitis.

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Key information

Conditions

Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections

Age range

16 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura university hospital

Al Mansurah, Dakahlia Governorate, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients of both genders aging between 18 and 65 years who present with acute appendicitis.
Patients with perforated appendicitis will be also included.

Exclusion criteria

Patients with appendicular mass, appendicular abscess, generalized peritonitis.
Patients with other causes of acute abdomen as revealed intraoperatively.
Patients taking long course of steroid therapy or immunosuppressive treatment,
Patients unwilling to participate in the trial.

Treatment and study plan

Irrigation

Procedure

upon closure of the peritoneum gentamicin-saline solution (160 mg of gentamicin in 400 ml of normal saline 0.9%) will be used for irrigation of every layer of the wound before its closure

Primary outcomes

Surgical site infection

Time frame: 2 months after surgery

The incidence of superficial site infection as detected by clinical examination on follow-up

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

A Randomized Trial on Wound Irrigation in Prevention of Surgical Site Infection After Appendectomy

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Dec 12, 2018
Registry last updated: May 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed