Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Inclusion criteria

• Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism

Exclusion criteria

• Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
• Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
• Testicular Ectopia (testis outside of normal migration path)
• Anorchidism and evanescent testicles, united or bilateral
• Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
• Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological.