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OpenTrials
Completed

NCT Number: NCT03072615

Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS

The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

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Key information

Conditions

Portal Hypertension Digestive System Diseases Hypertension, Portal Liver Cirrhoses Liver Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • TIPS insertion and had reliable SWE or TE measurement

Exclusion criteria

  • contraindication for TIPS
  • no reliable SWE or TE measurement

Treatment and study plan

Stiffness measurement

Diagnostic Test

Transient Elastopgraphy (TE) or Shear-Wave-Elastography

Primary outcomes

  1. Survival

    Time frame: 3 months

Secondary outcomes

  1. Acute-on-chronic Lvier failure

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Jonel Trebicka

Other

Registry information

Acronym: TIPS-SWE

Important dates

Study start
2013
Primary completion
2015
Study completion
2016
First posted
Mar 7, 2017
Registry last updated
Mar 7, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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