Robotic Versus Laparoscopic Liver Resection for Hepatocellular Carcinoma

The objective of the study is to investigate the long-term outcomes of minimally invasive liver surgery (robotic vs laparoscopic) for hepatocellular carcinoma patients of stage BCLC 0-A. Data from two tertiary centers for liver surgery will be retrospectively reviewed. Patients will be divided in two cohorts (robot; laparoscopy). The primary endpoint will be recurrence-free and overall survival; secondary endpoints were incidence, pattern, and treatment of recurrences.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hepatocellular Carcinoma Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing robotic and laparoscopic resections
Histology-confirmed HCC of stage BCLC 0-A
Preserved liver function (Child score A-B)
Patients >18 years old

Exclusion criteria

Hand-assisted procedures
Non-elective surgery
Intraoperative switch to locoregional therapies (like radiofrequency or microwave ablation)
Non-histologically confirmed HCC
Mixed hepato-cholangiocarcinoma.

Treatment and study plan

Minimally invasive liver resection

Procedure

Patients underwent liver resection either by robotic or laparoscopic approach

Primary outcomes

Recurrence-free survival

Time frame: From the date of liver resection until the first documented HCC progression on follow-up imaging, assessed up to 116 months. The Minimum follow-up accepted was of 3 months postoperatively.

Recurrence was dated at the first HCC detection on follow-up imaging.
Overall survival

Time frame: From the date of liver resection until the date of death for any cause or the last follow-up available whichever came first, assessed up to 116 months. The Minimum follow-up accepted was of 3 months postoperatively.

Sponsors and collaborators

Lead sponsor

Ente Ospedaliero Cantonale, Bellinzona

Other

Registry information

Official study title

Recurrence ad Survival After Robotic Versus Laparoscopic Liver Resection in Very-early to Early (BCLC 0-A) Hepatocellular Carcinoma

Important dates

Study start: 2014
Primary completion: 2024
Study completion: 2024
First posted: Jul 11, 2024
Registry last updated: Jul 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed