RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

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Key information

Conditions

Tracheal Stenosis Respiratory Tract Diseases Subglottic Stenosis Tracheal Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Maryland

Baltimore, Maryland, 21201, United States

Location status: Recruiting

Location contact

Chenchen Zhang

CONTACT

[email protected]

4103288141

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with benign tracheal stenosis

Exclusion criteria

Malignancy. active infection

Treatment and study plan

Biopsy or surgery

Procedure

The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

Primary outcomes

RNA profile

Time frame: 1 year

The diseased mucosa will show a increased fibrosis and inflammation profile compared with that from normal mucosa

Study contacts

Contact information is provided by the study sponsor or research team.

Chenchen Zhang, MD

CONTACT

[email protected]

14103288141

Sponsors and collaborators

Lead sponsor

University of Maryland, Baltimore

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 2, 2025
Registry last updated: Dec 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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