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NCT Number: NCT06798142

Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning

This study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Toxic Encephalopathy Chemically-Induced Disorders Diquat Poisoning Nervous System Diseases Neurotoxicity Syndromes Poisoning

Sex eligibility

All sexes

Study type

Observational

Primary location

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210008, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • history of oral exposure to diquat solution reported by patient or proxy;
  • a specimen for the diquat plasma concentration collected immediately upon admission;
  • documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans.

Exclusion criteria

  • they had ingested other toxins in addition to diquat (qualitative toxicological screening tests);
  • diquat was not detected in specimens, or plasma concentration data were unavailable;
  • patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours;
  • data on organ damage were not unavailable;
  • combined with other central nervous system injuries other than toxic encephalopathy.

Treatment and study plan

extracorporeal treatment

Procedure

Extracorporeal treatments included hemoperfusion (HP) and continuous veno-venous hemodiafiltration (CVVHDF).

Primary outcomes

  1. Survival outcome

    Time frame: 28 days within the index date of presentation at emergency department

Sponsors and collaborators

Lead sponsor

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Other

Registry information

Official study title

Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning: A Multi-Center Cohort Study

Important dates

Study start
2022
Primary completion
2024
Study completion
2026
First posted
Jan 29, 2025
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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