Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.

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Key information

Conditions

Incidence of Thyroid Cancer in Long Standing MNG Endocrine System Diseases Goiter Thyroid Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Medicine University of Khartoum

Khartoum, 11111, Sudan

About this study

This is a prospective cohort study The objective is to determine the incidence of cancer in patients with long standing goitres( more than 10 years ) who present for surgery in Khartoum Teaching Hopspital - Sudan.

Introduction: goitre is endemic in Sudan with prevalence ranging between 5-42% in different regions of the country. Patients are referred for surgery only if they develop pressure symptoms.

The incidence of thyroid carcinoma is high in endemic goitrous areas. Determining the risk of cancer in patient with long standing goitres may help in early early referral and early surgical intervention.

Methods: This is prospective cohort study including 160 patients with long standing goitrers of 10 years or more who presented from March 2017 to September 2017 to Khartoum Teaching Hospital-Sudan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients with long standing goitres of 10 years or more

Exclusion criteria

Treatment and study plan

Histopathology

Diagnostic Test

Thyroidectomy for patients and histological examination of specimen to determine incidence of malignancy.

Primary outcomes

Rate of malignancy

Time frame: March 2017-September 2018

Rate of malignancy in resected goitre specimens

Sponsors and collaborators

Lead sponsor

University of Khartoum

Other

Collaborators

Sudan Medical Specialization Board

Registry information

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: May 9, 2024
Registry last updated: May 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed