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OpenTrials
Completed

NCT Number: NCT07575243

Thyroidectomy-specific Enhanced Recovery After Surgery (ERAS) Protocol

Thyroidectomy is generally considered a low-to-moderate risk operation; however, postoperative pain, nausea/vomiting, and prolonged hospital stays remain common issues. Enhanced Recovery After Surgery (ERAS) pathways aim to optimize perioperative care and accelerate recovery. This study evaluates the effectiveness and safety of a standardized ERAS pathway in patients undergoing elective thyroidectomy. The prospective ERAS cohort is compared with a historical control group receiving conventional care to assess the impact on the length of hospital stay, postoperative pain, opioid consumption, and complication rates.

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Key information

Conditions

Thyroid Diseases Endocrine Gland Neoplasms Endocrine System Diseases Goiter Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Neoplasms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Surgical Oncology Department, South Egypt Cancer Institute, Assiut University

Asyut, Asyut Governorate, 71516, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-75 years
  • ASA physical status I-III.
  • Scheduled for elective thyroidectomy for benign or malignant disease.

Exclusion criteria

  • Re-operative thyroid surgery
  • Concomitant neck dissection
  • Inability to comply with the ERAS pathway

Treatment and study plan

Enhanced Recovery After Surgery protocol

Procedure

This incorporates standardized preoperative counseling, reduced fasting, multimodal opioid-sparing analgesia, total intravenous anesthesia, selective drain use, early oral intake and mobilization, and PTH-guided calcium supplementation

Other names: ERAS

Conventional perioperative care

Procedure

This often involves prolonged preoperative fasting, opioid-based analgesia, and delayed mobilization

Primary outcomes

  1. Length of hospital stay

    Time frame: Up to 30 days post-surgery

    Hours from surgery end to discharge

Secondary outcomes

  1. Postoperative pain scores

    Time frame: Assessed in the first 24 hours postoperatively

    Mean Numeric Rating Scale (NRS-11; 0 = no pain to 10 = worst imaginable pain) at rest in 24 hours. NRS scores are categorized as mild (1-3), moderate (4-6), or severe (7-10).

  2. Total opioid consumption

    Time frame: Within first 24 hours

    Oral Morphine Milligram Equivalents (MME)

  3. Postoperative nausea and vomiting (PONV)

    Time frame: Up to 24 hours postoperatively

    Incidence of PONV

  4. Rate of postoperative hypocalcemia

    Time frame: First 30 days from the surgery

    Biochemical and symptomatic occurrences

  5. 30-day unplanned readmission rate

    Time frame: Up to 30 days postoperative

    Number of unplanned readmissions

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

A Comprehensive Enhanced Recovery After Surgery (ERAS) Protocol for Thyroidectomy

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
May 8, 2026
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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