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NCT Number: NCT06828952

Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis

From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells/dL, CRP mg/L, appendix diameter mm, modified Alvarado score , and adult appendicitis score .

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Key information

Conditions

Conservative Management Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections

Age range

16 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Assiut University

Asyut, 71515, Egypt

About this study

Expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . It is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female patients é diagnosis of acute appendicitis .
  • Patients with ages: from 16 to 60 years old.

Exclusion criteria

  • complicated AA (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor).
  • inflammatory bowel disease.
  • inability to co-operate and give informed consent.
  • diffuse peritonitis.
  • antibiotic documented allergy & allergy to contrast media .
  • Patients with serious comorbid conditions DM & renal insufficiency, serum creatinine > 150 μmol/l .
  • Pregnant & lactating patient.
  • Patients with bleeding diathesis and those on anticoagulants.
  • Patients with advanced malignancies & patient on immunosuppressive drugs .
  • Patients with previous appendectomy.
  • Extreme of age.

Treatment and study plan

Ceftriaxone

Drug

ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Drug

Conservative management

Primary outcomes

  1. Risk factors of failure of conservative treatment in acute non complicated appendicitis

    Time frame: One year

    modified Alvarado score and adult appendicitis score

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Mohammed Hussein Sayed Ahmed Razeen, MBBCh

CONTACT

[email protected]

+2001099414358

Mohamed Taher Gamal Amin Taher, MBBCh &MD &PHD

CONTACT

[email protected]

+2001091289046

Sponsors and collaborators

Lead sponsor

Ahmed Mohammed Hussein Sayed

Other

Collaborators

  • Assiut University

Registry information

Acronym: appendicitis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 17, 2025
Registry last updated
Feb 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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