Rimonabant in Obesity Over a 2-Year Duration (RIO-Europe)

Inclusion criteria

• body mass index (BMI) e30 kg/m2 in patients with or without comorbidities, or BMI >27 kg/m2 in patients with treated or untreated hypertension and/or treated or untreated dyslipidemia.
• stable body weight (variation <5 kg within 3 months prior to screening visit);

Exclusion criteria

• History of very low-calorie diet within 6 months prior to screening visit; or history of surgical procedures for body weight loss (eg, stomach stapling, bypass);
• Presence of any clinically significant psychiatric , neurological or endocrine disease
• Presence of treated or untreated type 1 or type 2 diabetes);
• SBP >165 mmHg and/or DBP >105 mmHg on 2 consecutive visits from the screening to the inclusion visit;
• History of myocardial infarction or unstable angina pectoris within 6 months prior to screening visit; and history of stroke within 6 months prior to screening visit;
• Administration of anti-obesity drugs or other drugs for body weight reduction within 3 months prior to screening visit;

The investigator will evaluate whether there are other reasons why a patient may not participate.